结肠药物输送系统基于可膨胀和微生物可降解的高甲基丁:涂层工艺和体外性能
Saliha Moutaharrik1, Luca Palugan1, Matteo Cerea1
1Department of Pharmaceutical Sciences, Section of Pharmaceutical Technology and Legislation "M.E. Sangalli", University of Milan, Via G. Colombo 71, 20133 Milan, Italy.
Pharmaceutics
|April 27, 2024
概括
高甲基丁涂层提供双重向的口腔结肠输送. 这些系统利用时间和微生物群依赖的释放,显示了针对药物输送应用的希望.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学 材料科学 材料科学
背景情况:
- 开发有效的口腔结肠输送系统对于有针对性的药物释放至关重要.
- 结合时间和微生物群依赖机制的双重准策略提高了交付特异性.
研究的目的:
- 设计和评估使用高甲烯 (HM) 作为涂层剂的口腔结肠输送系统.
- 研究喷涂和粉末涂层技术对pectin涂层特性和药物释放的影响.
- 确认双重向释放潜力,包括微生物群依赖的降解.
主要方法:
- 含有药物的核心被涂上可膨胀/可生物降解的多糖体内层和使用HM点的胃抗性外层.
- 用喷雾涂层和粉末涂层涂上素涂层,用基甲基纤维素 (HPMC) 作为粉末涂层的粘合剂.
- 涂层质量,厚度,屏障特性和药物释放概况在体外进行了评估,包括使用患者衍生细菌的测试.
主要成果:
- 喷涂和粉末层的HM点均产生了脉动性药物释放,具有可重现的滞后阶段.
- 粉末涂层,特别是含有更细微的pectin分数的涂层,显示出更好的质量和屏障性能.
- HM丁涂层表现出微生物群依赖的降解,在克罗恩病患者细菌的存在下触发更早的释放.
结论:
- 高甲基丁是口腔结肠输送系统的可行的涂层材料.
- 开发的系统具有双重准释放机制,对时间和肠道微生物群都有反应.
- 基于pectin的涂层提供了一个有希望的,自然衍生的选择,用于向的结肠药物输送.
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