含有富含安东素的石榴花提取物,具有抗氧化和抗糖尿病作用的益生菌系统
Anna Gościniak1, Natalia Rosiak1, Daria Szymanowska1,2
1Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.
Pharmaceutics
|April 27, 2024
概括
稳定载体,如环氧和牙增强石榴花提取物.
科学领域:
- 药理学和营养保健品药理学和营养保健品
- 食品科学与技术 食品科学与技术
- 微生物学 微生物学
背景情况:
- 石榴花提取物,富含安东素,提供健康益处,包括抗氧化和抗糖尿病作用.
- 氨酸的治疗潜力受到其不稳定性的限制.
- 研究稳定载体,以提高石榴花提取物的稳定性和生物可用性.
研究的目的:
- 评估稳定载体 (HP-γ-CD,α-CD,Me-β-CD,伊努林,阿拉伯口香糖) 对石榴花提取物的抗氧化和抗糖尿病活性的影响.
- 评估这些载体对提取物稳定性,释放特征和益生菌活性的影响.
- 在这些输送系统中确认pelargonidin-3,5-glucoside的促进健康的特性.
主要方法:
- 福利埃变换红外光谱 (FT-IR) 用于相互作用分析.
- 显微镜成像用于结构检查.
- 对α-氨酶和α-葡萄糖酶进行抑制试验,以确定抗糖尿病活性.
- DPPH和CUPRAC对抗氧化活性进行了测试.
- 高性能液体染色学 (HPLC) 用于量化pelargonidin-3,5-glucoside.
- 在pH值6.8和1.2的体外释放研究.
- 在90°C的稳定性评估.
- 使用10种细菌菌株进行前生物潜在评估.
主要成果:
- 稳定载体显著改善了石榴花提取物的抗氧化和抗糖尿病功能.
- 在准备的系统中观察到佩拉戈尼丁-3,5-葡萄糖酸的增强稳定性和受控释放概况.
- 开发的输送系统显示出显著的前生物活性.
结论:
- 稳定载体有效增强石榴花提取物的健康促进特性,特别是其抗糖尿病和益生菌作用.
- 这些优化的输送系统有助于改善有益化合物的利用,例如pelargonidin-3,5-glucoside.
- 该研究强调了载体介导输送系统在提高天然生物活性化合物的疗效方面的潜力.
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