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Updated: Jun 27, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
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在向癌症治疗中使用Mirk/Dyrk1B激酶抑制剂

Nikolaos Kokkorakis1,2, Marios Zouridakis3, Maria Gaitanou1

  • 1Laboratory of Cellular and Molecular Neurobiology-Stem Cells, Hellenic Pasteur Institute, 11521 Athens, Greece.

Pharmaceutics
|April 27, 2024
PubMed
概括

Mirk/Dyrk1B激酶抑制剂通过抑制癌细胞存活和化学抵抗,对向癌症治疗具有前途. 开发选择性抑制剂至关重要,以最大限度地减少对类似的激酶 (如Dyrk1A) 的非目标效应.

关键词:
在Mirk/Dyrk1B激酶中,Mirk/Dyrk1B激酶是一个X射线晶体结构.灭症 (apoptosis) 是一种死亡的过程.癌症 癌症 癌症 癌症 癌症癌症干细胞是癌症干细胞.抑制剂 抑制剂 抑制剂静止是一种静止.有针对性的癌症治疗.

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