用于输送植物性化合物的适合剂:一篇评论
Joana Gamboa1, Pedro Lourenço1, Carla Cruz1,2
1Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior (CICS-UBI), Av. Infante D. Henrique, 6201-506 Covilhã, Portugal.
Pharmaceutics
|April 27, 2024
概括
天然化合物在治疗疾病方面表现有前途,但存在交付方面的挑战. 作为药物输送系统中的向配体,阿普塔默提高了这些天然化合物的疗效和选择性,用于医疗应用.
科学领域:
- 生物医学科学 生物医学科学
- 药理学 药理学是指药理学的学科.
- 纳米技术纳米技术
背景情况:
- 自然化合物为感染,炎症和癌症提供治疗潜力.
- 限制包括药物动力学不佳,低特异性和毒性.
- 有针对性的药物输送系统可以克服这些局限性.
研究的目的:
- 审查阿普坦体作为自然化合物递送的向剂的潜力.
- 讨论基于aptamer的药物输送的新兴趋势和发展.
- 突出自然产品与aptamer系统的组合,以增强医疗应用.
主要方法:
- 关于阿普坦和天然产品药物输送的科学文献的综述.
- 对针对性传递应用的阿普坦特征的分析.
- 讨论自然化合物与胺基功能化载体的集成.
主要成果:
- 由于其稳定性,特异性和易于修改,aptamers是有效的向连接体.
- 将天然产品与基于aptamer的系统相结合,可以提高选择性和有效性.
- 这一战略扩大了天然化合物的治疗应用.
结论:
- 亚体是一种有前途的工具,可以有针对性地提供天然化合物.
- 通过aptamer介导的输送可以提高天然产品的治疗指数.
- 这种方法意味着在药物输送和医药领域的新战略.
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