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同轴3D生物打印过程研究和血管支架上的性能测试

Jiarun Sun¹, Youping Gong^1,2, Manli Xu³

¹School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.

|April 27, 2024

概括

这项研究提出了一种新的同轴3D生物打印方法,用于创建血管化的组织支架. 制造的脚手架显示出心血管疾病治疗的有希望的生物相容性和机械性能.

科学领域:

生物材料工程生物材料工程
组织工程是组织工程.
心血管研究研究心血管研究

背景情况:

治疗心血管疾病需要具有复杂血管网络,良好的生物相容性和机械强度的血管化组织.
制造血管化组织的现有方法在复制复杂的血管结构方面面临挑战.

研究的目的:

开发一种使用同轴3D生物打印和模具技术制造血管化组织的方法.
为了优化制造参数,以创建功能性血管支架.

主要方法:

制定了同轴喷气和血管网络的理论模型.
进行模拟分析以确定初步的工艺参数.
使用酸生物墨和化交叉连接器制造的血管支架,优化流量,度和打印参数.

主要成果:

制造的血管支架表现出令人满意的可降解性,吸水性和机械性能.
细胞实验显示,人类静脉内皮细胞 (HUVECs) 在长达七天的时间内在支架内有良好的增殖和生物相容性.
制造的血管结构满足了血管支架的初始要求.

结论:

同轴3D生物打印与模具方法相结合是制造血管化组织支架的可行方法.
开发的方法和优化的参数产生了血管支架,其性能适合潜在的心血管应用.

关键词:

在3D生物打印中使用3D生物打印生物架构是生物架构.同轴喷气式喷气机的同轴喷气机有限元分析是有限元分析.血管网络血管网络

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