在COVID-19前后的病原体抗菌耐药性模式在重症监护病房中的病原体
Andreea-Loredana Golli1, Ovidiu Mircea Zlatian2, Monica Laura Cara1
1Department of Public Health and Management, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
在COVID-19之后,重症监护室 (ICU) 的抗菌素耐药性显著增加. 关键的病原体,如克莱布西埃拉 spp. 黄金葡萄球菌和黄金葡萄球菌对关键抗生素具有更高的耐药性,这给治疗带来了挑战.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 关键护理医学 关键护理医学
背景情况:
- COVID-19大流行影响了全球的医疗保健系统,可能会影响抗菌素耐药性 (AMR) 模式.
- 重症监护病房 (ICU) 是一个关键的环境,AMR对患者的结果构成重大威胁.
研究的目的:
- 在COVID-19大流行之前和之后,调查ICU患者中细菌病原体抗微生物耐药性模式的趋势.
- 识别表现出耐药率显著变化的特定病原体和抗生素.
主要方法:
- 一项回顾性研究分析了来自ICU患者样本的细菌病原体.
- 从COVID-19前期和COVID-19后期的培养数据的比较.
- 对常见病原体的耐药性率的统计分析,如金黄色葡萄球菌,克莱布塞拉菌,大肠杆菌和阿辛托巴克特菌等.
主要成果:
- 克莱布西埃拉 spp. 的种类. 显示显著增加对胆固醇素, gentamicin 和 aztreonam 的耐药性.
- 大肠杆菌和Acinetobacter sp. 这两种细菌. 显示出对胆固醇抗性的显著增加.
- 超过50%的金黄色葡萄球菌菌株是耐甲氨酸的金黄色葡萄球菌 (MRSA),对多西环素,线化物,利芬素和提科普拉宁的耐药性增加.
结论:
- 在COVID-19后的格拉姆阴性病原体中观察到抗菌素耐药性的显著增加趋势.
- 对最后手段抗生素的耐药性显著增加,使严重感染的治疗策略复杂化.
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