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Updated: Jun 7, 2026

A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line
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A Parasite Rescue and Transformation Assay for Antileishmanial Screening Against Intracellular Leishmania donovani Amastigotes in THP1 Human Acute Monocytic Leukemia Cell Line

Published on: December 30, 2012

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通过基于光偏振的高通量查识别Leishmania捐赠的PEX5-PTS1相互作用抑制剂

Trong-Nhat Phan1,2,3, Kyu-Ho Paul Park4, David Shum4

  • 1Institute of Applied Science and Technology, School of Technology, Van Lang University, Ho Chi Minh City 700000, Vietnam.

Molecules (Basel, Switzerland)
|April 27, 2024
PubMed
概括

研究人员确定了新的小分子抑制剂,针对Leishmania寄生虫中的PEX5-PTS1相互作用. 这一发现为开发抗寄生虫药物治疗莱什曼病和相关疾病提供了一个有希望的新策略.

关键词:
莱什曼尼亚 (Leishmania) 是一种病.在PEX5 PEX5上使用.高通量选的高通量选抑制剂抑制剂的使用过氧体的准信号

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Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...