肠道微生物群组成和CoronaVac三剂后的长期疫苗免疫性之间的关联
Li-Na Zhang1, Jing-Tong Tan1, Ho-Yu Ng2
1Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong.
Vaccines
|April 27, 2024
概括
肠道细菌如Eubacterium rectale和Collinsella aerofaciens与较低的COVID-19疫苗免疫力有关. 在接种CoronaVac疫苗后,Streptococcus salivarius可能会支持更好的长期免疫反应.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 中和抗体水平随着时间的推移而降低COVID-19疫苗接种后.
- 了解影响疫苗免疫性因素对于长期保护至关重要.
研究的目的:
- 调查基线肠道微生物组成和CoronaVac疫苗三剂后免疫性之间的关联.
- 为了确定特定的细菌物种和代谢途径,预测对COVID-19疫苗接种的免疫反应.
主要方法:
- 对36名三剂量CoronaVac接种者的前性队列研究.
- 病毒微中和 (vMN) 试验用于评估基线和疫苗接种后的一年中和标位.
- 便样本的枪支DNA元基因组测序和LEfSe分析以确定细菌物种和代谢途径.
主要成果:
- 18名受试者在接种疫苗后一年表现出较低的免疫反应.
- 在低响应者中,Eubacterium rectale,Collinsella aerofaciens和Streptococcus salivarius的丰富度较高.
- 特定的肠道细菌与参与抗炎功能的代谢途径相关,影响疫苗免疫性.
结论:
- 某些肠道细菌,包括E. rectale和C. aerofaciens,在接种CoronaVac疫苗后与长期免疫性降低有关.
- 肠道微生物组可能在调节对COVID-19疫苗免疫反应方面发挥重要作用.
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