在多次mRNA-1273疫苗接种后接受血造细胞移植患者的尖端特异性B细胞记忆反应:一项纵向观察性研究
Elena Pettini1, Annalisa Ciabattini1, Fabio Fiorino1,2
1Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, 53100 Siena, Italy.
Vaccines
|April 27, 2024
概括
异质造血细胞移植患者需要多次mRNA-1273疫苗剂量,以建立强大的SARS-CoV-2免疫反应. 重复接种疫苗可以提高特异性B细胞和抗体水平,这对这个脆弱群体至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 血液学 血液学 血液学
背景情况:
- 全基性造血细胞移植 (allo-HCT) 患者极易受到SARS-CoV-2感染的严重结果的影响.
- 有限的数据存在于COVID-19疫苗免疫性在Allo-HCT接受者,特别是关于记忆反应.
研究的目的:
- 评估免疫反应,包括尖端特异性记忆B细胞和抗体动力学,在多次mRNA-1273疫苗剂量后,在alo-HCT接受者中评估免疫反应.
- 为了比较alo-HCT接受者的免疫反应与健康对照者的免疫反应.
主要方法:
- 在Allo-HCT接受者的Ig切换CD19+细胞内分析尖端特异性B细胞.
- 从基线到四个疫苗剂量,监测尖端特异性抗体水平和ACE2/RBD结合抑制活性.
- 艾洛-HCT接受者与健康对照者之间的免疫反应动力学的比较.
主要成果:
- 多次mRNA-1273剂量显著增加了特异性B细胞和HCT接受者的抗体反应.
- 辅助剂量进一步扩大了B细胞和改善了抗体反应,即使是对初级系列没有反应的人.
- 艾洛-HCT接种者表现出较慢的动力学,但在重复接种疫苗后达到与健康对照人群相比的抗体水平.
- 观察到对BA.1变种的高交叉抑制活性.
结论:
- 艾洛-HCT接种者需要重复mRNA-1273疫苗剂量,以达到与健康个体相似的SARS-CoV-2特定免疫反应.
- 重复接种疫苗对于那些可能对初始COVID-19疫苗系列反应有限的弱势群体至关重要.
- 该研究强调了针对免疫受损患者量身定制的疫苗接种策略的重要性.
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