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在H13N8流感病毒中发现了大量的亚型内部重组

Sofia Feoktistova¹, Marya Sayganova¹, Kseniya Trutneva¹

¹Federal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, 125315 Moscow, Russia.

|April 27, 2024

概括

在俄罗斯的水禽中检测到A型流感病毒 (IAV) H13N8. 这种在俄罗斯首次发现的重组病毒强调了正在进行的IAV进化和监视的必要性.

科学领域:

病毒学病毒学
流行病学流行病学
鸟类健康鸟类健康

背景情况:

流感A型病毒 (IAV) 是全球健康的重大威胁,导致季节性流感,并可能造成大流行.
水鸟是IAV的主要自然储备,促进它们的传播和进化.
了解流感病毒的多样性,特别是野生鸟类种群的多样性,对于公共卫生至关重要.

研究的目的:

调查俄罗斯布里亚提亚共和国野生迁徙鸟类中A型流感病毒的流行率和遗传特征.
识别和测序新型IAV亚型,特别关注那些具有潜在的动物感染或流行病影响的亚型.
分析新发现的IAV菌株的进化史和重组事件.

主要方法:

2020年在贝加尔湖附近从野生迁徙鸟类收集和分析了3018个便样本.
使用分子方法检测流感A病毒的存在.
阳性样本的全基因组测序以确定病毒亚型和遗传构成.

主要成果:

11个便样本检测出A型流感病毒,特别是H13N8亚型病毒呈阳性.
确定的病毒,A/Unknown/Buryatia/Arangatui-1/2020,代表了在俄罗斯记录的第一个H13N8亚型,公开可用的序列数据.
基因组分析显示,A/Unknown/Buryatia/Arangatui-1/2020是一种重组病毒,可能是几十年来来自全球不同地区的祖先病毒之间基因交换的结果.

结论:

在俄罗斯发现重新分类的H13N8病毒强调了流感病毒的动态演变和地理分布.
这一发现强调了各大洲禽流感病毒储存库的相互联系.
对未经充分研究的流感亚型的持续监测和研究对于早期检测和疫情准备至关重要.

关键词:

H13N8 H13N8 H13N8 H13N8 H13N8 H13N8 H13N8 H13N8 H13N8 H13N8 H13N8 H13N8 H13N8 H13N8 H13N8 H13N8 H13N8 H13N8 H13N8 H13N8 流感A型病毒感染者进行重新分类,重新分类.监控监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督监督

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