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Updated: Jun 27, 2025

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

关于SPR阵列传感芯片与微集成的实验研究.

Wanwan Chen¹, Peng Wang¹, Bin Li^1,2

¹Department of Precision Instrument, Tsinghua University, Beijing 100084, China.

Sensors (Basel, Switzerland)

|April 27, 2024

概括

本研究介绍了一种微流体系统,集成了微膜,用于表面等离子体共振 (SPR) 传感. 开发的微可靠地控制流体流动,证明适用于SPR阵列传感应用.

科学领域:

微流体学微流体学
生物感应是一种生物感应.
表面等离子体共振 (SPR) 是一种

背景情况:

微流体系统对于生物传感中精确的流体处理至关重要.
集成的微提供了对样品和试剂输送的增强控制.
表面等离子共振 (SPR) 是一种广泛用于生物化学分析的无标签检测技术.

研究的目的:

设计和制造一种新型的微流体系统,内置SPR传感微门.
为了描述微的性能和可靠性.
为了证明系统在SPR阵列传感应用中的实用性.

主要方法:

使用聚甲基 (PDMS) 和聚甲基甲烯酸盐 (PMMA) 制造一个分层的微流体芯片.
微与电极的集成,以使用导电方法进行功能验证.
测试微门的关闭压力和时间依赖的操作.
多个微的协调运行,用于连续的流体流量控制.
与SPR阵列传感系统集成,用于NaCl溶液注入和检测.

主要成果:

微门在0.3MPa的控制压力下显示完全关闭.
发现微门的运行取决于施加的压力和持续时间.

关键词:

在 SPR 阵列检测中使用 SPR 阵列检测.电解质的导电性电解质的导电性微流体系统的微流体系统气动微型门气动微型门

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协调的微操作使得顺序样品和试剂的输送成为可能.

该系统在SPR检测实验中成功控制了NaCl溶液注射.

在不同的芯片区域观察到相变曲线,验证了系统性能.

结论:

开发的微流体系统与集成的微门是可靠和功能性的.
微适用于SPR阵列传感中的精确流体控制.
这项技术为先进的基于微流体的生物传感平台提供了潜力.