使用频域近红外光谱学最大限度地提高前额叶皮层氧化测量的可靠性和精度
Elizabeth K S Fletcher1,2,3,4, Joel S Burma1,2,3,4,5, Raelyn M Javra1,2,3,4
1Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 4N1, Canada.
Sensors (Basel, Switzerland)
|April 27, 2024
概括
频域近红外光谱 (FD-NIRS) 提供了有效的皮质氧化测量方法. 虽然1分钟的记录足以证明氧和,但更长的记录时间 (≥4分钟) 提高了对血红蛋白评估的临床效用.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 医疗技术 医疗技术 医学技术
背景情况:
- 频域近红外光谱 (FD-NIRS) 是一种评估皮质氧化的非侵入性工具.
- 关于FD-NIRS测量的临床有效性和可重现性的研究有限.
研究的目的:
- 用FD-NIRS.评估有效和可重复的前额叶皮层氧化测量的最佳记录时间.
- 评估FD-NIRS在测量皮质氧化率中的日内和日间可靠性.
主要方法:
- 通过对1-10分钟测量的反向分析 (n=52) 用变化系数和布兰德-阿尔特曼图表来评估有效性.
- 可复制性通过15名参与者每天两次进行2分钟的测量进行评估,持续5天.
- 皮层氧化参数包括氧和度 (StO2),总血红蛋白 (THb),氧血红蛋白 (HbO) 和脱氧血红蛋白 (HHb).
主要成果:
- 一分钟的FD-NIRS记录显示了对StO2和THb的足够有效性.
- 4分钟或更长时间的记录为HbO和HHb测量提供了更大的临床实用性.
- FD-NIRS表现出良好的日间可靠性,对于StO2和THb.确定了最小的可检测变化.
- 在StO2和THb水平上观察到性别差异,但在变化方面没有.
结论:
- FD-NIRS是评估皮层氧化的可靠方法,适用于现场应用.
- 一分钟的记录时间足以进行有效的StO2和THb评估.
- 建议使用更长的记录时间 (≥4分钟) 来提高临床效用,特别是对于HbO和HHb.
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