Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

What are Estimates?01:06

What are Estimates?

5.0K
It isn't easy to measure a parameter such as the mean height or the mean weight of a population. So, we draw samples from the population and calculate the mean height or mean weight of the individuals in the sample. This sample data acts as a representative measure of the population parameter. These sample statistics are known as estimates. 
The estimate for the mean of a sample is denoted by ͞x, whereas the mean of the population is designated as μ. Further, parameters such...
5.0K
Estimation of the Physical Quantities01:05

Estimation of the Physical Quantities

4.2K
On many occasions, physicists, other scientists, and engineers need to make estimates of a particular quantity. These are sometimes referred to as guesstimates, order-of-magnitude approximations, back-of-the-envelope calculations, or Fermi calculations. The physicist Enrico Fermi was famous for his ability to estimate various kinds of data with surprising precision. Estimating does not mean guessing a number or a formula at random. Instead, estimation means using prior experience and sound...
4.2K
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

482
This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
482
Prediction Intervals01:03

Prediction Intervals

2.3K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y. 
2.3K
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

52
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
52
Econometric Views (EViews)01:29

Econometric Views (EViews)

141
Econometric Views, often stylized as EViews, is a package that merges statistical analysis with econometric studies. It is designed to provide tools for time series analysis, forecasting, and econometric model simulation. The software originated from MicroTSP software and has evolved significantly since its inception in 1981. The history of EViews is marked by a continuous effort to enhance its computational speed and user interface. It was initially developed for large computing systems but...
141

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Intersectional inequalities in somatic symptom severity: A trans-diagnostic MAIHDA analysis of SOMACROSS data.

Journal of psychosomatic research·2026
Same author

Interactions of blood biomolecules with early rhythm control in atrial fibrillation patients: Exploratory analysis of the EAST-AFNET 4 Biomolecule Study.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2026
Same author

Global prevalence and determinants of hospital-acquired COVID-19: protocol for a systematic review and meta-analysis.

BMJ open·2026
Same author

Mapping the network of persistent somatic symptoms across diseases: Cross-sectional and longitudinal analyses from the SOMACROSS research unit.

Journal of psychosomatic research·2026
Same author

Early treatment of Atrial fibrillation for Stroke prevention Trial in acute STROKE (EAST-STROKE): protocol for an international investigator-initiated, prospective, randomised, open, blinded endpoint assessment (PROBE) interventional multi-centre trial.

European stroke journal·2026
Same author

Effectiveness and Safety of Early Rhythm Control in Patients With Atrial Fibrillation and Chronic Kidney Disease.

Journal of the American College of Cardiology·2026

相关实验视频

Updated: Jun 27, 2025

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity
07:28

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity

Published on: January 21, 2017

7.0K

估计和概念的当前发展.

Alexander Fierenz1, Antonia Zapf1

  • 1Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Pharmaceutical statistics
|April 27, 2024
PubMed
概括
此摘要是机器生成的。

治疗研究中的估计和概念随着多次适应而发展. 本文回顾了关键方面,对间流事件的修改策略,以及临床研究中的实施方法.

关键词:
在ICH E9附录中.估计和估计和估计.间流动事件是一个间流动事件.

更多相关视频

Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments
13:00

Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments

Published on: January 23, 2017

9.9K
Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.3K

相关实验视频

Last Updated: Jun 27, 2025

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity
07:28

Psychophysically-anchored, Robust Thresholding in Studying Pain-related Lateralization of Oscillatory Prestimulus Activity

Published on: January 21, 2017

7.0K
Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments
13:00

Measuring Attention and Visual Processing Speed by Model-based Analysis of Temporal-order Judgments

Published on: January 23, 2017

9.9K
Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.3K

科学领域:

  • 生物统计学 生物统计学
  • 临床试验 临床试验
  • 药学研究 药学研究

背景情况:

  • 估计和框架是为了澄清临床研究中的治疗目标而引入的.
  • 随着时间的推移,对最初的估计和概念的调整和扩展已经出现.
  • 了解估计值对于准确解释治疗研究结果至关重要.

研究的目的:

  • 突出估计和概念的重要方面.
  • 识别和介绍估计和框架的各种扩展.
  • 讨论处理间流事件的策略,并在临床研究中实施estimand.

主要方法:

  • 进行了文献研究,以确定估计和框架的不同扩展.
  • 对间流事件的修改策略的审查.
  • 研究了在临床研究中实施估计方法的示例.

主要成果:

  • 已经开发了估计和概念的几个调整和扩展.
  • 介绍了处理间流动事件的修改策略.
  • 展示了在临床试验中实施估计方法.

结论:

  • 估计仍然是一个活跃的研究领域.
  • 预计将对估计和概念进行进一步的探索和开发.
  • 估计对稳健的临床试验设计和分析至关重要.