病理特征与甲时性结直肠癌风险之间的关联
Ye Zhang1,2, Aung Ko Win1,2,3, Enes Makalic1
1Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
International journal of cancer
|April 27, 2024
概括
患有同步瘤或不匹配修复缺陷 (MMR-D) 瘤的结直肠癌 (CRC) 幸存者面临更高的甲时性CRC发展风险. 这一发现建议更新这些高风险患者群体的监测指南.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 癌症流行病学 癌症流行病学
背景情况:
- 结肠直肠癌 (CRC) 幸存者有发展新的初级结肠直肠癌的风险,称为元慢性CRC.
- 识别最初瘤的病理特征可以帮助完善CRC幸存者的监测策略.
研究的目的:
- 调查原发性结直肠癌的病理特征与发展甲时性结直肠癌的风险之间的关联.
- 为了告知对现有的结直肠癌幸存者的监测指南的潜在更新.
主要方法:
- 在美国,加拿大和澳大利亚 (1997-2012) 招募了6085例结直肠癌患者的基于人口的队列.
- 患者被前性跟踪到2022年,不包括患有林奇综合征或MUTYH突变的人.
- 考克斯回归模型用于分析甲时慢性CRC的风险,定义为在初始诊断后至少一年诊断出新的初级CRC.
主要成果:
- 在12年的中位数随访期间,138例 (2.3%) 病例发展为甲时性CRC.
- 同步结直肠癌患者的甲时结直肠癌风险增加了3.4倍 (aHR:3.36).
- 不匹配修复缺陷 (MMR-D) 瘤与超慢性CRC风险增加72%相关 (aHR: 1.72),而无差异组织学显示风险降低 (aHR: 0.23).
结论:
- 患有同步原发性瘤或MMR缺乏瘤的结肠直肠癌幸存者患上甲时性CRC的风险明显更高.
- 目前针对结直肠癌幸存者的监测指南可能会从加强对这些特定病理特征的患者的监测中受益.
- 这些发现支持基于个体瘤特征的个性化监测策略,以改善结直肠癌幸存者的结果.
相关概念视频
02:07Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
02:21Cancers Originate from Somatic Mutations in a Single Cell
11.9K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
11.9K
01:17Chronic Bowel Disorders: Introduction
446
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
446
01:30Inflammatory Bowel Disease II: Crohn's Disease
222
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
222
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
172
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
172