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影响持续和间歇性等离子体转化在患有严重高甘油三血症的患者临床结果的因素
1Department of Clinical and Chemical Pathology, Division of Transfusion Medicine, Apheresis unit of Kasr Alainy Blood Bank, Faculty of Medicine, Cairo University, Cairo, Egypt.
概括
较短的血酶程序显著改善了甘油三清除. 使用专素作为替代液体和肝素作为抗凝剂,特别是在连续无凝技术下,优化了严重高甘油三血症的甘油三去除.
科学领域:
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學.
- 血液学 血液学 血液学
背景情况:
- 急性过高甘油三血是等离子体酶的第三类指示.
- 血作为替代液体 (RF) 可以补充消耗的脂蛋白脂酶.
- 肝素作为抗凝剂可能通过释放脂蛋白脂酶来增强甘油三清除.
研究的目的:
- 调查替代液体 (白蛋白与新鲜冷血) 和抗凝剂 (ACD-A与肝素) 在血合成期间对甘油三水平的影响.
- 为了比较持续流量 (Optia) 与间歇流量等离子体 (Haemonetics) 在患有严重高甘油三血症的患者中.
主要方法:
- 一项涉及27名严重高甘油三血症 (SHTG) 患者的研究.
- 对四名患有复发性SHTG的患者进行了对对分析,比较连续与间歇性血相结合.
- 专与新鲜冷血 (FFP) 作为替代液体以及ACD-A与肝素作为抗凝剂的评估.
主要成果:
- 较短的等离子体酶程序与甘油三酸 (TG) 的显著下降相关.
- 与酸盐相比,作为RF的白蛋白与氨酸作为抗凝剂导致更大的TG减少和更少的会议.
- 连续无光技术 (Optia) 比间歇流 (Haemonetics) 更有效,需要更少的时间和更少的会议来进行可比的TG去除.
结论:
- 较短的程序持续时间是有效的甘油三清除的主要因素.
- 连续异体技术,特别是用白蛋白作为RF,提高了TG去除效率.
- 氨酸在与Optia系统一起使用时似乎可以优化TG去除.
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