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缩症将较低的新奇性相关的脑部位置连接性与临床前AD的认知衰退联系在一起

Christoph Schneider^1,2, Prokopis C Prokopiou^1,2, Kathryn V Papp^2,3

¹Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Alzheimer's & dementia : the journal of the Alzheimer's Association

|April 27, 2024

概括

减少部连接到中间叶连接与大脑缩和认知衰退有关,特别是与β-粉样蛋白. 这表明这种途径在临床前阿尔茨海默氏症中起着神经保护作用.

科学领域:

神经科学是一个神经科学.
神经成像是一种神经成像.
阿尔茨海默氏症疾病研究研究

背景情况:

位于心位 (LC) 的tau病理与北上腺素信号缺陷,中间叶缩 (MTL) 和认知障碍有关.
研究LC和MTL (FC_LC-MTL) 之间的功能连接对于了解临床前阿尔茨海默病 (AD) 是至关重要的.

研究的目的:

检查FC_LC-MTL对布拉克阶段区域皮质缩的影响.
为了确定FC_LC-MTL对认知功能的影响.
评估粉样β (Aβ) 在这些关系中的调节作用.

主要方法:

功能性磁共振成像 (fMRI) 和粉样β (Aβ) 定子发射断层扫描数据分析来自128个认知正常个体.
与新奇性相关的FC_LC-MTL与纵向皮质缩和认知变化的关联.
对FC_LC-MTL,缩和认知关系上的Aβ调节的研究.

主要成果:

下FC_LC-MTL与布拉克II期区域的缩相关. 截面.
从长度来看,降低的FC_LC-MTL与布拉克 2-4期的缩有关,特别是在更高的Aβ水平时.
布拉克第二阶段区域的缩调解了FC_LC-MTL和随后的认知衰退之间的联系.

结论:

FC_LC-MTL在Aβ相关的皮质缩中起作用.
LC-MTL通路可能提供神经保护作用,防止临床前AD的认知衰退.
这些发现与动物模型一致,该动物模型显示,在诺拉上腺素信号功能障碍后的缩.

关键词:

阿尔茨海默氏症的疾病是阿尔茨海默氏症.缩性缩 (英语:Atrophy atrophy) 是一种损伤.贝塔-氨基胺是一种β-氨基胺生物标志物生物标志物连接性的连接性.这里是locus coeruleus的地方.磁共振成像技术的使用中间叶的叶定子发射断层扫描 (PET).

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