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Human Genetics

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

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[手术后认知功能障碍的遗传基础]

V A Saltanova^1,2, O A Kicherova¹, L I Reikhert¹

¹Tyumen State Medical University, Tyumen, Russia.

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

|April 27, 2024

概括

像TOMM40和APOE这样的遗传标记可能会影响术后认知功能障碍. 这篇综述详细介绍了与麻醉引起的认知障碍相关的基因和机制,总结了基因变异的证据.

科学领域:

神经科学是一个神经科学.
遗传学是一个遗传学.
麻醉学麻醉学

背景情况:

手术后认知功能障碍 (POCD) 是麻醉和手术后的一个重大问题.
准确的POCD病因学仍然不完全理解,遗传倾向是研究的一个关键领域.

研究的目的:

审查和综合现有关于与POCD发展相关的遗传标记物的文献.
阐明病原遗传机制,将特定的基因与麻醉后的认知障碍联系起来.

主要方法:

对调查遗传变异和POCD的研究进行系统文献综述.
分析涉及已识别基因的已报告的致病遗传途径.

主要成果:

包括TOMM40,APOE,TREM2,METTL3,PGC1a,HMGB1和ERMN在内的几种基因被强调为POCD的潜在贡献者.
有证据表明,这些基因的变异影响了手术后认知功能障碍的风险和发展.

结论:

遗传因素对POCD的易感性和表现起着至关重要的作用.
对这些遗传标记及其机制的进一步研究可以为POCD的有针对性的预防和治疗策略提供信息.

关键词:

长期麻醉是一种长期麻醉.术后认知功能障碍术后认知功能障碍

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