患者衍生异种移植模型用于转化前列腺癌研究和药物开发
1Australian Prostate Cancer Research Centre - Queensland, Centre for Genomics and Personalised Health, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research Institute, Brisbane, QLD, Australia. lisa.philp@qut.edu.au.
Methods in molecular biology (Clifton, N.J.)
|April 27, 2024
概括
患者衍生异种移植 (PDX) 为前列腺癌 (PCa) 研究提供了高可靠性模型. 这些模型准确地反映了患者的瘤,使得有效的临床前治疗测试和推进精准医学.
科学领域:
- 在瘤学瘤学.
- 临床前研究 临床前研究
- 翻译医学是一种翻译医学.
背景情况:
- 患者衍生异种移植 (PDX) 是通过将患者瘤移植到小鼠中来产生的.
- PDXs作为精密医学和治疗测试的化身.
- 前列腺癌 (PCa) PDXs准确地代表了患者的瘤特征.
研究的目的:
- 描述PCa PDX殖民地的创建和维护.
- 在小鼠中概述PDX维护的最佳实践.
- 详细说明PDX在临床前药物测试中的应用.
主要方法:
- 从一个具有良好特征的PDX建立PDX维护殖民地.
- 在免疫缺陷或人性化小鼠中连续传递和维持PDX瘤.
- 在临床前治疗剂开发和测试中应用PDX.
主要成果:
- PDX瘤保持患者的瘤架构,组织病理学和基因组景观.
- 小鼠的PDX药物反应与患者的临床结果相关.
- 已确定的PCa PDXs代表了各种各样的亚型,包括对雄激素敏感的瘤和抵抗割的瘤.
结论:
- PDXs是前列腺癌临床前治疗概念验证的黄金标准.
- PDX模型对于推进翻译研究和药物开发至关重要.
- 该资源有助于在研究实验室采用PCa PDX模型.
相关概念视频
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
02:43Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...