关于omega-3脂肪酸和缺血性中风的风险
Zsuzsanna Ament1,2, Amit Patki3, Varun M Bhave4
1Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Translational stroke research
|April 27, 2024
概括
鱼类中发现的omega-3脂肪酸多可萨赫萨酸 (DHA) 的较高水平与缺血性中风的风险较低有关. DHA还调解了鱼类消费对中风的保护作用.
科学领域:
- 心血管科学 心血管科学
- 营养科学 营养科学
- 代谢学 代谢学 代谢学
背景情况:
- 缺血性中风仍然是全球残疾和死亡的主要原因.
- 了解可修改的风险因素,包括饮食成分及其代谢途径,对于预防中风至关重要.
- 脂质组概况为与疾病风险相关的代谢变化提供了洞察力.
研究的目的:
- 为了研究血脂质谱和发生性缺血性中风风险之间的关联.
- 探索饮食模式,特别是鱼类摄入量与脂质特征之间的关系.
- 确定多可萨赫萨酸 (DHA) 是否调解了鱼类摄入量与中风风险之间的关联.
主要方法:
- 这项研究利用了来自"脑卒中地理和种族差异的原因" (REGARDS) 队列的数据.
- 探索性因子分析用于将195个血脂质整合到底层因子中.
- 考克斯的比例危险模型,线性回归和反向几率比重 (IORW) 用于分析关联和调解.
主要成果:
- 富含多可沙赫酸 (DHA) 的脂质因子与发生性缺血性中风风险相反相关 (HR=0.88;P=2.79×10−4).
- 这种富含DHA的脂质因子与健康的饮食模式有关,特别是鱼类摄入量 (β=1.96;P=1.36×10−4).
- 研究人员发现,多可沙赫萨酸 (DHA) 调解了鱼类摄入量与中风风险降低之间的30%关系 (P=5.78×10−3).
结论:
- 含有DHA的血脂与发生性缺血性中风的风险相反.
- 饮食中的鱼类摄入量与含有DHA的脂质水平较高有关.
- DHA在调解鱼类消费对缺血性中风的心脏保护作用方面发挥着重要作用.
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