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在增强的外部反推力下,心室-动脉合的血液动力学:一个优化的双源一次性参数模型

Sheng-Fu Liao¹, Yong-Jiang Li², Sen Cao¹

¹Institute of Cardio-Cerebrovascular Medicine, Central Hospital of Dalian University of Technology, Dalian, Liaoning 116033, China; School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, Dalian, Liaoning 116024, China.

Computer methods and programs in biomedicine

|April 27, 2024

概括

增强的外部反推力 (EECP) 通过最大限度地减少心室输出工作来优化心室动脉合 (VAC). 这项研究揭示了EECP.

科学领域:

心血管生理学心血管生理学
生物医学工程生物医学工程
血液动力学血液动力学

背景情况:

增强的外部反推力 (EECP) 通过改善血液动力学来帮助缺血性心血管疾病的管理.
电脑脑内皮质调节心室后负荷,增强心脏输出和器官 perfusion.
对于EECP对心室动脉合 (VAC) 的影响尚不清楚.

研究的目的:

研究EECP对左心室和动脉系统之间的动态相互作用的急性影响.
在EECP下从心室输出工作的角度分析心室动脉合 (VAC).

主要方法:

开发了一个神经网络辅助的算法,以使用普通微分方程 (ODEs) 建模大动脉压力和流速之间的关系.
构建了一个包含心脏和EECP压力源的一次性参数模型 (LPM).
通过使用心室输出工作来表征VAC,通过最小化成本函数来验证.

主要成果:

一个三级的ODE准确地描述了大动脉压力和流量之间的血液动力学关系.
开发了一种优化的双源LPM,配有三个储能元件.
LPM模拟显示,在不同的EECP压力下,VAC将心室输出工作降到最低.

结论:

在EECP下,心室 - 动脉合受最小心室输出工作原则的约束.
这个原理可以作为确定大动脉压力和流速波形的标准.
这些发现提供了关于VAC和EECP对心血管系统的影响的见解.

关键词:

加强了外部对冲的作用.血液动力学血液动力学一次性参数模型.最小输出的工作原则.神经网络的神经网络风 - 动脉合器的合.

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