骨折风险评估工具为老年人骨质疏松症的查在资源有限的环境中
Andrea D Stephanus1, Sara Cristina L Ramos2, Osvaldo S Netto3
1Department of Gerontology, Catholic University of Brasília, Brasília, Federal District, Brazil.
概括
10年FRAX®关节骨折概率有效选低资源环境中50岁以上的成年人骨质疏松风险. 该工具是DXA扫描的有价值替代品,提供了显著的预测性能.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 医学诊断 医学诊断 医学诊断
背景情况:
- 骨质疏松症对公众健康构成重大挑战,特别是对老年人来说,导致死亡率和发病率增加.
- 低收入和中等收入国家 (LMICs) 在获得双能X射线吸收计 (DXA) 早期发现骨质疏松症方面面临挑战.
研究的目的:
- 评估FRAX®评分的有效性,作为一个全民查工具,用于在LMIC中对50岁及以上个体的骨质疏松风险.
- 为了比较FRAX®关节骨折概率与FRAX®主要骨折概率的预测性能,以确定骨质疏松症风险.
主要方法:
- 追溯性队列研究涉及864名参与者.
- 使用c统计数据对接收器操作特征 (ROC) 曲线进行比较分析,以评估FRAX®评分的性能.
- 危险比率 (HR) 和95%信心区间 (CI) 的计算,统计学意义设置为p<0.05.
主要成果:
- 与10年FRAX®重大骨折概率相比,10年FRAX®骨折概率 (没有BMD) 在预测骨质疏松风险方面表现优越 (AUROC:0.71对0.67,p<0.001).
- 在FRAX®关节骨折概率显示出更高的预测性能和在2到10年的随访期间的净益.
- 对于10年FRAX®关节骨折概率的1.9%的截止值实现了92.9%的负预测值.
结论:
- 10年FRAX®骨骨折概率,估计不包括骨矿物密度,是一个有效的查工具,用于质疏松风险在个人超过50在LMICs.
- 这种基于FRAX®的方法为骨质疏松风险评估提供了可行的替代方案,在DXA访问有限的情况下.
更多相关视频
07:12Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
Published on: September 28, 2017
8.2K
04:00Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
Published on: July 26, 2024
516
相关概念视频
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:27Fractures: Bone Repair
3.2K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.2K