在帕金森病中皮层和皮层下功能连接和认知障碍
Brooke E Yeager1, Hunter P Twedt1, Joel Bruss2
1Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City 52242, USA.
NeuroImage. Clinical
|April 27, 2024
概括
帕金森病 (PD) 的认知障碍与大脑网络连接的改变有关. 较低的连接在前端对象网络 (FPN) 和像突出网络 (SAL) 和默认模式网络 (DMN) 这样的网络之间与PD患者的认知功能较差相关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 帕金森病 (PD) 是一种神经退行性疾病,影响运动和认知功能.
- 虽然PD的运动网络功能障碍得到了充分的研究,但认知障碍的神经支柱仍然不太了解.
- 确定与PD认知衰退相关的特定大脑网络变化对于有针对性的干预至关重要.
研究的目的:
- 研究帕金森病患者的休息状态功能连接和认知功能之间的关系.
- 检查皮质正规网络 ( Salience 网络,前双层网络,默认模式网络) 和 PD 基底质网络在认知障碍患者中的变化.
- 阐明网络内部和网络之间的连接在PD中观察到的认知缺陷中的作用.
主要方法:
- 利用了来自帕金森氏症进展标志物倡议 (PPMI) 队列的静止状态功能磁共振成像 (rs-fMRI) 数据.
- 分析了突出网络 (SAL) 内的功能连接,以及突出网络 (SAL),前端对象网络 (FPN),默认模式网络 (DMN) 和基底状腺网络 (BGN) 之间的功能连接.
- 与蒙特利尔认知评估 (MoCA) 评分作为82名PD患者认知功能的指数相关的rs-fMRI连接性测量.
主要成果:
- 蒙特利尔认知评估 (MoCA) 较低的PD患者的得分与前端对象网络 (FPN) 内的网络内连接性降低有关.
- 在突出网络 (SAL) 和基底腺网络 (BGN) 之间观察到网络间连接性下降.
- 较低的MoCA分数还与SAL和默认模式网络 (DMN) 之间的网络间连接性减少以及FPN和DMN之间的网络间连接性减少相关.
结论:
- 帕金森病的认知障碍与内部网络和网络之间的功能连接的中断有关.
- 特定的网络改变,包括减少FPN完整性和改变SAL,BGN和DMN相互作用,有助于PD的认知缺陷.
- 这些发现突出了导致PD认知衰退的复杂神经网络功能障碍,为未来的研究和治疗策略提供了潜在的目标.
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