杜皮卢马布改善了慢性鼻炎与鼻的睡眠质量
Giuseppe Riva1, Marco Garetto1, Mario Borgione1
1Division of Otorhinolaryngology, Department of Surgical Sciences, University of Turin, Via Genova 3, Turin, Italy.
American journal of otolaryngology
|April 27, 2024
概括
杜皮卢马布显著改善睡眠质量,并降低了严重的慢性鼻炎与鼻息肉 (CRSwNP) 的患者睡眠呼吸暂停的风险. 这些好处是在三个月内观察到的,并在整个治疗过程中持续存在.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 肺部病理学 肺部病理学
- 睡眠医学 睡眠医学
背景情况:
- 严重的慢性鼻炎与鼻息肉 (CRSwNP) 显著影响患者的生活质量,特别是睡眠质量.
- 耐火或复发的CRSwNP病例往往需要先进的治疗选择.
- 杜比卢马布已成为严重CRSwNP的有希望的治疗方法.
研究的目的:
- 评估dupilumab对CRSwNP患者睡眠质量的影响.
- 评估dupilumab治疗后临床参数和睡眠相关结果的变化.
主要方法:
- 一项观察性回顾性研究包括了45名用dupilumab治疗的CRSwNP患者.
- 收集的数据包括临床参数 (NPS,ACT),生活质量 (SNOT-22),睡眠质量 (PSQI,ESS) 和睡眠呼吸暂停风险 (STOP-BANG) 在基线和3,6和12个月.
- 进行了统计分析,以确定随时间变化的意义.
主要成果:
- 杜皮卢马布治疗导致鼻息肉得分 (NPS),喘控制测试 (ACT) 和中鼻结局测试22 (SNOT-22) 的得分显著改善.
- 通过SNOT-22,爱普沃思睡眠度量 (ESS) 和匹兹堡睡眠质量指数 (PSQI) 评估的睡眠质量显示出显著改善 (p < 0.001),睡眠不良从88.9%降至5.7%.
- 通过STOP-BANG评估的睡眠呼吸暂停风险显著下降,从68.9%降至2.8% (p < 0.001).
结论:
- 杜皮卢马布有效地改善了严重CRSwNP患者的睡眠质量.
- 杜皮卢马布也显著降低了这个患者群体中睡眠呼吸暂停的风险.
- 杜皮卢马布对睡眠的积极影响在三个月内就显而易见,并在持续治疗期间保持.
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