检查抗生素在分鼻整形的管理:一个系统的审查和元分析
Cristina Benites1, Muhammad Usman Awan1, Heli Patel1
1Department of Medical Education, Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, United States of America.
American journal of otolaryngology
|April 27, 2024
概括
预防性抗生素并不能显著降低术后感染率在血清整形,鼻整形或鼻整形 (SRP). 目前的证据表明,对于这些常见的耳鼻喉手术,应该重新评估抗生素使用指南.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 基于证据的医学基于证据的医学.
背景情况:
- 隔膜整形,鼻膜整形和隔膜鼻膜整形 (SRP) 是常见的手术.
- 手术后感染是由于鼻腔细菌菌群的潜在风险.
- 预防性抗生素在预防这些感染的有效性是有争议的.
研究的目的:
- 为了评估预防性抗生素在降低术后感染率后的预防性抗生素的有效性.
- 通过系统性审查和元分析来分析现有研究.
主要方法:
- 按照PRISMA指南对PubMed,Cochrane和Web of Science数据库进行系统审查.
- 包括随机对照试验,盲目的研究和队列研究.
- 对15项涉及2225名患者的研究进行了元分析,以确定感染率.
主要成果:
- 对15项研究 (2225名患者) 的分析显示,预防性抗生素没有显著降低感染率 (OR 0.65,95% CI: [0.23,1.89]).
- 在研究设计,抗生素时间和手术技术方面观察到显著的异质性.
结论:
- 没有实质性的证据支持常规使用预防性抗生素,以防止在隔膜整形,鼻整形或SRP后感染.
- 研究方法的不一致性和潜在的偏见限制了目前的理解.
- 需要进一步进行高质量的随机对照试验,以建立基于证据的指导方针.
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