患有阿片类药物使用障碍的人群中并发性物质使用障碍的患病率:系统性审查和元分析
Thomas Santo1, Natasa Gisev1, Gabrielle Campbell2
1National Drug and Alcohol Research Centre (NDARC), UNSW Sydney, Sydney, New South Wales, Australia.
The International journal on drug policy
|April 27, 2024
概括
伴随性物质使用障碍 (SUDs) 在阿片类药物使用障碍 (OUD) 患者中很常见,超过一半的人经历了当前的SUD,并且在他们的一生中占比更高. 在这个人群中,可卡因,酒精和大麻使用障碍是最常见的非阿片类药物SUD.
科学领域:
- 成 药物 药物 药物 药物
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 伴随性物质使用障碍 (SUDs) 显著恶化了阿片类药物使用障碍 (OUD) 患者的结果,增加了过量服用和死亡的风险.
- 在OUD人群中估计特定非阿片类SUD的流行率对于有针对性的干预至关重要.
研究的目的:
- 系统地审查和元分析OUD患者中特定非阿片类SUD的患病率.
- 为各种非阿片类药物SUD提供当前和终身患病率估计.
主要方法:
- 进行了对Embase,PsycINFO和MEDLINE数据库 (1990-2022) 的全面搜索.
- 包括符合DSM或ICD标准的研究,用于评估OUD人群中的非阿片类SUD.
- 随机效应的元分析被用于统计流行率估计,元回归检查异质性.
主要成果:
- 分析了194项涉及77,212名OUD参与者的研究数据.
- 任何当前非阿片类药物SUD的患病率为59.5%,终身患病率为72.0%.
- 可卡因 (30.5%),酒精 (27.1%) 和大麻 (22.7%) 使用障碍是目前最常见的并发性SUD,在研究中观察到显著的异质性.
结论:
- 伴随性非阿片类药物SUD的高发病率强调了对OUD患者综合治疗的关键需求.
- 这些流行率估计可以指导OUD亚群的有效治疗和减少危害策略的开发.
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