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产前心理困扰和人类胎盘中的11β-HSD2基因表达:系统性审查和元分析

Angham Ibrahim Tartour¹, Tawanda Chivese¹, Safa Eltayeb²

¹Department of Population Medicine, College of Medicine, QU Health, Qatar University, P. O. Box:2713, Doha, Qatar.

Psychoneuroendocrinology

|April 27, 2024

概括

产前心理困扰微弱地降低了胎盘的11-Beta-Hydroxysteroid脱酶异酶2型 (11-β HSD2) 基因表达. 这可能会影响胎儿的神经发育和后代的健康结果.

科学领域:

生殖生物学生殖生物学
发育神经科学的发展神经科学.
遗传学是一个遗传学.

背景情况:

胎盘通过11-Beta水氧类固醇脱酶异酶2型 (11-β HSD2) 酶调节胎儿的皮质醇暴露.
产前心理困扰 (PPD) 可能通过改变胎盘功能来影响胎儿发育.

研究的目的:

系统地审查和元分析PPD对胎盘11-βHSD2基因表达的影响.
探索连接PPD,胎盘11-βHSD2和胎儿神经发育的机制性途径.

主要方法:

16项纵向观察性研究的系统综述和元分析.
在多个数据库中进行了搜索 (PubMed,Embase,Scopus,APA PsycInfo®,ProQuest论文).
针对PPD (抑郁,焦虑,感知压力) 和胎盘11-β HSD2表达的聚合调整回归系数.

主要成果:

在PPD和胎盘11-β HSD2基因表达之间发现了弱负相关性.
第三个三个月的PPD暴露与较低的11-βHSD2水平更相关.
PPD和胎盘11-β HSD2变化与孕产妇/胎儿健康结果有关,女性后代更容易受到伤害.

结论:

产前心理困扰在调节胎盘11-β HSD2基因表达方面起到适度的作用.
需要进一步研究更大的样本大小和先进的方法来检测小效应大小.
对于未来的研究来说,对母亲的种族,三个月,分娩方式和婴儿性别的控制至关重要.

关键词:

11β-氧类固醇脱酶2型生命早期的风险早期的风险胎儿重编程胎儿重编程基因表达基因表达基因表达胎盘胎盘胎盘胎盘产前心理困扰产前心理困扰

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