Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Modeling immune responses to autologous and allogeneic human stem cell-derived islet grafts in vivo.

JCI insight·2026
Same author

Kidney Transplantation in Two Highly Sensitized Candidates after CAR T-Cell Therapy.

The New England journal of medicine·2026
Same author

PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity.

The Journal of experimental medicine·2026
Same author

Differential Contributions of IgM and IgG Autoantibodies to Serologic IA2 Reactivity in Type 1 Diabetes.

Biomolecules·2026
Same author

Epigenetic adaptation of beta cells across lifespan and disease.

Nature metabolism·2026
Same author

Carbazole Core-Based Small Molecule as an Effective 4-<i>tert</i>-Butylpyridine Replacement for Perovskite Solar Cells.

The journal of physical chemistry letters·2026

相关实验视频

Updated: Jun 27, 2025

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

9.5K

使用机器学习和人类小岛的单细胞转录组测量来建模1型糖尿病的进展.

Abhijeet R Patil1, Jonathan Schug2, Chengyang Liu3

  • 1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Epigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Cell reports. Medicine
|April 27, 2024
PubMed
概括

机器学习通过分析胰腺小岛单细胞基因表达来准确预测1型糖尿病 (T1D) 风险. 这种方法有助于早期发现T1D自身免疫,改善患者的治疗结果.

关键词:
自抗体阳性自抗体.人类岛屿小岛机器学习是机器学习.一个单细胞RNA-seqq.第1类糖尿病 1型糖尿病

更多相关视频

Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets
11:34

Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets

Published on: July 18, 2019

16.4K
Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
10:03

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

1.8K

相关实验视频

Last Updated: Jun 27, 2025

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
10:09

Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets

Published on: May 11, 2015

9.5K
Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets
11:34

Single-cell RNA Sequencing and Analysis of Human Pancreatic Islets

Published on: July 18, 2019

16.4K
Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice
10:03

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

1.8K

科学领域:

  • 免疫学 免疫学 免疫学
  • 基因组学就是基因组学.
  • 计算生物学 计算生物学

背景情况:

  • 1型糖尿病 (T1D) 涉及免疫媒介的胰腺β细胞的破坏.
  • 早期发现T1D自身免疫性至关重要,但仍然具有挑战性.
  • 目前的免疫疗法旨在延迟T1D的发病.

研究的目的:

  • 用单细胞岛屿基因表达来评估用于早期T1D预测的机器学习.
  • 在自身抗体阳性个体中模拟T1D发展概率.
  • 识别与T1D相关的共享基因表达特征.

主要方法:

  • 利用梯度增强算法进行基因表达分析.
  • 从T1D和非糖尿病捐赠者的胰腺组织中模拟的单细胞转录变化.
  • 评估了风险人群T1D发展的预测准确性.

主要成果:

  • 机器学习模型根据独特的基因特征预测了T1D的可能性.
  • 大多数自身抗体阳性捐赠者被正确地归类为非糖尿病患者.
  • 在T1D模型中确定了不同细胞类型的共享基因特征.

结论:

  • 机器学习为早期T1D检测提供了一个可行的策略.
  • 单细胞基因表达分析可以揭示与T1D相关的分子模式.
  • 这项研究为T1D研究中的计算方法树立了先例.