在lophotrochozoans中是否有可能对雌激醇受体进行信号传导?
A M Murillo Ramos1, J Y Wilson1
1Department of Biology, McMaster University, 1280 Main St. West, Hamilton, ON L8S 4K1, Canada.
General and comparative endocrinology
|April 27, 2024
概括
雌激素受体 (ER) 在lophotrochozoa中广泛存在,但它们的精确生理作用和雌激醇生物合成能力尚不清楚. 建议对Capitella teleta等物种进行进一步的研究,以阐明ER信号通路.
科学领域:
- 进化生物学是进化的生物学.
- 内分泌学 在内分泌学.
- 无脊椎动物动物学 不脊椎动物动物学
背景情况:
- 雌激素受体 (ERs) 是古老的,在多种不同的lophotrochozoans中发现,包括软体动物,类动物和类动物.
- 之前的研究,主要是在软体动物中,表明构成性活跃的ERs,而类动物研究表明结合体激活受体.
- 这突出了关于信号在lophotrochozoan血统中的功能意义和进化轨迹的关键问题.
研究的目的:
- 审查和综合现有证据的雌二醇受体信号在lophotrochozoans,特别关注类动物和类动物.
- 探索ERs在这些类中的进化,表达和生理作用.
- 评估非软体动物lophotrochozoans中de novo雌激素生物合成的潜力.
主要方法:
- 对有关ER信号在lophotrochozoans的一致和不一致证据的文献综述.
- 对参与类固醇生成的基因 (例如,CYP11,CYP17,CYP19) 的基因组数据进行分析.
- 检查了研究ER激活和生理反应的体外和体内研究.
主要成果:
- 雌激素受体存在于许多lophotrochozoan物种中,一些体外数据支持雌激醇结合和转录激活.
- 表达模式表明在发育,繁殖和消化中的作用,但这些都是高度特定于物种的.
- 关于de novo雌激醇生物合成的证据是不确定的;虽然有些基因存在,但关键的酶步骤和产品确认往往缺乏.
结论:
- 尽管ERs在大多数lophotrochozoa中广泛存在,但ERs在大多数lophotrochozoa中的生理作用仍然难以捉摸.
- 关于非软体动物lophotrochozoa的雌醇生物合成能力存在显著的数据缺口.
- 由于现有的基因组数据和实验可操作性,Capitella teleta,Platyneris dumerilii和Brachionus manjavacas等物种被提议作为未来研究的模型生物.
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