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外源性甲状腺素增加了胰岛素抵抗性OLETF大鼠的心脏GLUT4转位

Dora A Mendez¹, José G Soñanez-Organis², Xue Yang¹

¹Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, CA, USA.

Molecular and cellular endocrinology

|April 27, 2024

概括

甲状腺激素 (T4) 疗法可以改善胰岛素抵抗的心脏葡萄糖代谢. 外源性甲状腺素 (T4) 增加了葡萄糖吸收和糖解,同时减少了胰岛素抵抗性大鼠的脂肪酸使用,这表明糖尿病心肌病的治疗潜力.

科学领域:

心脏病学心脏病学
内分泌学在内分泌学.
代谢科学代谢科学

背景情况:

胰岛素耐药性将心脏ATP生产转移到脂肪酸,损害葡萄糖代谢.
这种转变增加了氧化应激,脂毒性和线粒体功能障碍,可能导致心肌病.
甲状腺激素 (TH) 影响葡萄糖代谢,但它们在胰岛素抵抗期间对心脏的影响尚不清楚.

研究的目的:

研究外源性甲状腺素 (T4) 对胰岛素抵抗性大鼠心脏葡萄糖代谢的影响.
评估T4在胰岛素抵抗下对心脏脂肪酸代谢的影响.

主要方法:

使用了耐胰岛素的Otsuka长埃文斯托库希玛脂肪 (OLETF) 鼠和瘦长埃文斯托库希玛Otsuka (LETO) 鼠.
鼠被分配到对照组或T4治疗组.
在T4给药后,分析了心脏葡萄糖和脂肪酸代谢标志物.

主要成果:

在OLETF大鼠中,T4显著增加了GLUT4基因表达和膜转位.
在OLETF心脏中,T4增强了关键的糖解酶 (p-AS160,PFK-1,hexokinase II).
在OLETF大鼠中,T4降低了卡尼丁棕基转移酶2 (CPT2) 的mRNA和蛋白质表达.

结论:

外源T4可增强胰岛素抵抗性大鼠的心脏葡萄糖吸收和新陈代谢.
T4治疗减少了心脏脂肪酸代谢,可能减轻了脂毒性.
在糖尿病心肌病中,L-甲状腺素对治疗基质代谢功能障碍充满希望.

关键词:

脂肪酸是一种脂肪酸.葡萄糖的新陈代谢.胰岛素耐药性胰岛素耐药性是一种代谢综合征是代谢综合征.兰德尔的循环周期甲状腺素甲状腺素

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