预防和治疗妄想的干预措施:随机对照试验的总体综述
Nicola Veronese1, Luisa Solimando1, Francesco Bolzetta2
1Geriatric Unit, Department of Medicine, University of Palermo, Palermo 90127, Italy.
Ageing research reviews
|April 27, 2024
概括
有效的痴呆症预防因患者群体和环境而异. 德克斯梅德托米丁和老年评估在老年手术患者中表现有希望,而对不同年龄组的其他干预措施有支持. 对于非手术设置需要进一步的研究.
科学领域:
- 老年病学和老年学.
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 妄想是一种普遍的疾病,预防和管理策略不太清楚.
- 现有的关于妄想干预的研究在各种人群和环境中是分散的.
研究的目的:
- 进行综合性审查,对所有预防性和治疗性妄想干预措施的证据进行综合和分类.
- 在不同患者群体,年龄段和临床环境中确定神经的有效干预措施.
主要方法:
- 在五个数据库中系统搜索到2023年3月15日发布的随机对照试验 (RCT) 的元分析.
- 包括59个系统性审查和元分析,包括485个独特的RCT和172,045名参与者.
- 专注于旨在降低妄想风险或严重性的干预措施.
主要成果:
- 高确定性证据支持德克斯梅德托米丁和全面的老年医学评估,以预防老年手术患者的妄想.
- 德克斯梅德托米丁和A2-上腺激动剂对分别在成人和儿科手术患者中有效预防痴呆症.
- 对于老年人痴呆症的预防,没有支持 Melatonergic 药物;适度的证据支持跨年龄组的其他药理和非药理干预措施.
结论:
- 有效的妄想预防策略是特定于人群和环境的.
- 结果可以为未来的临床指导方针提供信息,考虑干预的安全性和成本效益.
- 建议对非手术环境进行进一步的研究,以解决知识差距.
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