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免疫格局和进步的免疫疗法用于垂体神经内分泌瘤

Xiaopeng Guo¹, Yiying Yang², Zhihong Qian³

¹Department of Neurosurgery, Key Laboratory of Endocrinology of National Ministry of Health, China Pituitary Adenoma Specialist Council, China Pituitary Disease Registry Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

|April 27, 2024

概括

下垂体神经内分泌瘤 (pitNETs) 有一个尚未探索的免疫微环境. 针对巨细胞和T细胞等免疫细胞的免疫疗法,以及PD-L1等检查点,显示出治疗这些脑瘤的前景.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

下垂体神经内分泌瘤 (pitNETs) 是一种常见的原发性脑瘤.
瘤免疫微环境 (TIME) 和针对pitNETs的免疫疗法尚未得到研究.
了解pitNET免疫力对于开发有效的治疗方法至关重要.

研究的目的:

在 pitNETs 中回顾当前关于 TIME 的知识.
探索针对pitNETs的向免疫疗法的进展.
为了突出 pitNET 免疫格局的临床影响.

主要方法:

关于 pitNET 时间和免疫治疗的研究的综合文献综述.
免疫细胞透物 (巨细胞,T细胞) 的分析及其与瘤行为的相关性.
评估免疫检查点 (PD-L1) 和细胞因子/化学因子的作用.
对临床前和临床免疫治疗数据 (抗PD-L1,抗PD-1,抗CTLA-4) 的审查.

主要成果:

巨细胞和T细胞是洞穴中关键的免疫细胞.
在pitNET亚型中存在不同的免疫模式,影响瘤进展.
PD-L1表达与瘤生长和激素pitNETs的入侵有关.
细胞因子和化学因子与瘤亚型和免疫透具有复杂的关系.
临床前的抗PD-L1疗法在皮质营养不良的pitNET模型中显示出有效性.
临床免疫疗法 (抗PD-1/抗CTLA-4) 在垂体癌症中显示出更好的反应,而不是积极的pitNETs.

结论:

时间在坑里NETs是免疫治疗的有希望的目标.
对pitNET免疫力的进一步研究是有必要的.
向免疫疗法有可能用于治疗耐火性pitNETs和垂体癌症.

关键词:

化学物质化学物质是化学物质.细胞因子细胞因子免疫细胞是免疫细胞.免疫检查站检查站下垂体神经内分泌瘤的发生.

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