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Updated: Jun 27, 2025

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
06:58

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Published on: October 18, 2024

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CK1δ/ε激酶调节TDP-43酸化,并且是与ALS相关的TDP-43过酸化的治疗标

Vivian I Ko1, Kailee Ong2, Don W Cleveland3

  • 1Neuroscience Graduate Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0624, USA; Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0624, USA.

Neurobiology of disease
|April 27, 2024
PubMed
概括

氨酸激酶1delta/epsilon (CK1δ/ε) 直接酸化TARDNA结合蛋白43 (TDP-43),导致其在像ALS这样的神经退行性疾病中的聚合. 抑制CK1δ/ε可以减少病态TDP-43的酸化和聚合.

关键词:
肌缩性侧面硬化症 (AMLS) 是一种疾病.氨酸激酶1三角酶是什么凯赛因激酶1epsilon 是一种酸化是指酸化的方法.在TAR中发现的DNA结合蛋白 (TDP-43)在TDP-43蛋白质病变中.

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