立方体治疗减少了白氨酸的循环,但不会影响β-基β-甲基酸盐 (HMB) 的内源性产生
Martin Hagve1, Suzette L Pereira2, Dillon K Walker1
1Center for Translational Research in Aging & Longevity, Dept. Health and Kinesiology, Texas A&M University, College Station, TX, USA.
Metabolism: clinical and experimental
|April 27, 2024
概括
类药物降低了全身的白氨酸和氨酸的产生,这可能会影响肌肉健康. 需要进一步的研究来了解这种氨酸代谢变化是否会导致他类药物诱导的肌肉病变.
科学领域:
- 生物化学 生物化学
- 人体生理学 人体生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 类他类药物 (HMG-CoA减少酶抑制剂) 是一种被广泛处方的降胆固醇药物.
- 立方体使用与肌病性副作用有关,可能与减少辅酶Q10合成有关.
- 对于他类药物对HMG-CoA的前体白素代谢的影响尚不清楚.
研究的目的:
- 研究他类药物对氨酸及其代谢物 (KIC,HMB) 上游代谢的影响.
- 评估他类药物对其他分支链氨基酸 (BCAA) 代谢的影响.
主要方法:
- 一项配对前性研究,涉及12名接受他类药物治疗的超脂症老年人.
- 参与者在停止使用他类药物4周后进行了基线测量.
- 稳定同位素标记器测量了在重新引入他类药物之前和7天后的BCAA,酸和HMB的全身生产 (WBP).
主要成果:
- 静止剂治疗显著降低了白氨酸WBP的22% (p=0.0033) 和氨酸WBP的13% (p=0.0224).
- 在异黄素,酸或HMB的WBP中没有观察到任何显著的变化.
- 这些发现表明,他类药物对白氨酸和氨酸的周转量有上游影响.
结论:
- 立方体抑制HMG-CoA减少酶会影响白和氨酸的上游代谢.
- 观察到的白WBP损伤需要进一步调查其在他类药物相关肌肉副作用中的潜在作用.
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