乳腺发育在三岁之前的女性
Paul B Kaplowitz1, Peter A Lee2
1Division of Endocrinology, Children's National Hospital, George Washington School of Medicine and Health Sciences, 111 Michigan Avenue Northwest, Washington, DC 20010, USA.
Endocrinology and metabolism clinics of North America
|April 27, 2024
概括
过早的乳头痛 (PT) 在年轻女孩中很常见,通常在不影响正常青春期的情况下消失. 然而,实验室检测可能会与罕见的中部早熟青春期病例重叠,需要仔细诊断.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
背景情况:
- 3岁以下女孩的乳腺发育是常见的临床观察.
- 大多数早期乳腺发育的病例被诊断为过早的乳腺炎 (PT),通常会退化或没有进展.
- 患有PT的女孩通常会在预期的年龄出现正常的青春期发作和初潮.
研究的目的:
- 分析在非常年轻的女孩中早发性青春期和中部早发性青春期之间的诊断重叠.
- 突出区分PT和中心早期青春期的重要性,特别是在潜在的潜在病理病理病例中.
主要方法:
- 对临床病例的审查,在3岁或更年轻的女孩中呈现乳腺发育.
- 实验室检测的分析,包括基底和性腺激素释放激素 (GnRH) 刺激的性腺激素水平.
- 在被诊断为PT的女孩和中部早期青春期的女孩之间比较激素特征.
主要成果:
- 实验室结果,特别是基底和GnRH刺激的淋巴激素水平,显示PT和中央早熟青春期之间存在显著的重叠.
- 这种荷尔蒙重叠可能会使良性PT和病态中央早熟青春期的区分变得复杂,特别是在3岁以下的儿童中.
- 脑下垂体瘤被认为是3岁前中部早熟青春期罕见病例的常见原因.
结论:
- 在非常年轻的女孩中,区分早发性青春期和中部早发性青春期需要仔细的临床和实验室评估,因为荷尔蒙特征重叠.
- 虽然PT通常是良性的,不会影响未来的青春期,但与中部早发性青春期的重叠强调了对罕见的潜在疾病 (如下丘脑瘤) 保持警的必要性.
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