过早的青春期:一个务实的方法
1Division of Endocrinology, Children's National Hospital, Washington, DC, USA.
Endocrinology and metabolism clinics of North America
|April 27, 2024
概括
早发性青春期 (PP) 在5-9岁的儿童中很常见. 检测通常是不必要的,除非存在像快速生长这样的红旗,因为不太可能是可以治疗的疾病.
科学领域:
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
背景情况:
- 过早的青春期 (PP) 是常见的,通常是5~9岁儿童正常青春期的良性变体.
- 一些医疗保健提供者经常订购诊断测试,包括实验室分析和骨年龄评估,以排除其他疾病,如非经典的先天性上腺增生和淋巴体或上腺瘤.
研究的目的:
- 审查过早的青春期的自然历史.
- 评估在患有PP的儿童中进行例行实验室检测和骨年龄评估的必要性.
主要方法:
- 文学评论研究的自然历史过早的青春期的研究.
- 关于PP中实验室检测和骨龄评估的诊断收益率的证据分析.
- 评估与PP相关的临床红旗.
主要成果:
- 研究表明,如果没有特定的临床指标,如快速生长,进展或生殖器扩大,识别可治疗疾病的可能性很低.
- PP的自然史通常是良性的.
结论:
- 常规的实验室检测和骨年龄评估不建议在过早性青春期的患者.
- 检测应保留在初始临床评估时显示红旗的病例,例如快速进展或显著的生殖器发育.
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