诊断,治疗和结果的男性与中央早熟性青春期的早期青春期
Renée Robilliard1, Peter A Lee2, Lisa Swartz Topor1
1Division of Pediatric Endocrinology and Diabetes, Hasbro Children's Hospital, Providence, RI, USA; Warren Alpert Medical School of Brown University, Providence, RI, USA.
Endocrinology and metabolism clinics of North America
|April 27, 2024
概括
男性中部早发性青春期 (CPP),虽然很少见,但通常是潜在病理的信号. 淋巴激素释放激素激动剂 (GnRHa) 治疗是有效的,但需要更多的结果数据.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 神经内分泌学神经内分泌学
背景情况:
- 中部早期青春期 (CPP) 在男性中比女性少.
- 男性的CPP经常表明潜在的病理原因.
- 诊断依赖于识别早期青春期的迹象,如丸体积增加和中枢神经系统评估.
研究的目的:
- 审查男性中CPP的诊断和管理.
- 为了突出性腺激素释放激素激动剂 (GnRHa) 治疗的作用.
- 为了强调对综合结果数据的需求.
主要方法:
- 临床评估,包括检查青春期发育的身体检查.
- 中枢神经系统 (CNS) 的评估,以确定潜在的病变.
- 通过生长,身体征兆和水平来监测治疗的疗效.
主要成果:
- 在男性中,GnRHa疗法适用于CPP,通常与中枢神经系统病变的治疗一起进行.
- 治疗监测主要涉及临床和荷尔蒙评估.
- 现有的短期和长期数据表明GnRHa的有效性和安全性,但有限.
结论:
- 由于病理的可能性更高,男性的CPP需要进行彻底的调查.
- GnRHa是一种标准的治疗方法,但需要仔细监测.
- 进一步报告结果数据对于基于证据的实践至关重要.
相关概念视频
Signs of Puberty
334
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
334
Disorders of the Male Reproductive System
400
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
400
Infertility in Males
260
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
260
Adrenal Gland Disorders
1.5K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.5K
The Y Chromosome Determines Maleness
6.6K
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
6.6K
Testosterone: Functions and Regulation
640
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
640


