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Updated: Jun 27, 2025

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使用in4mer CRISPR/Cas12a多重淘汰平台进行高效的基因淘汰和基因相互作用选.

Nazanin Esmaeili Anvar1,2, Chenchu Lin1, Xingdi Ma1,2

  • 1Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Nature communications
|April 27, 2024
PubMed
概括

我们开发了一个新的基于Cas12a的基因查平台,用于对哺乳动物细胞中的基因相互作用进行可扩展的分析. 这种方法有效地识别了仿制合成致命物质,降低了成本并提高了测试性能.

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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