多发病性疾病集群与静脉血栓栓塞有关:一项扩展的横截面国家研究
Jonatan Ahrén1,2, MirNabi Pirouzifard3,4, Björn Holmquist5
1Center for Primary Health Care Research, Lund University/Region Skåne, Malmö, Sweden. jonatan.ahren@med.lu.se.
Journal of thrombosis and thrombolysis
|April 27, 2024
概括
非传染性疾病 (NCD) 的某些组合显著增加了静脉血栓栓塞 (VTE) 的风险. 识别这些多病症集群可以帮助预测VTE风险.
科学领域:
- 心血管疾病流行病学
- 公共卫生研究 公共卫生研究
- 慢性疾病管理 慢性疾病管理
背景情况:
- 多种疾病,定义为两个或两个以上的非传染性疾病 (NCD),是一个日益增长的社会挑战.
- 静脉血栓栓塞 (VTE) 是一种普遍的心血管疾病,但与静脉血栓塞风险相关的特定多病症集群尚不清楚.
研究的目的:
- 研究不同类型的常见非传染性疾病与静脉血栓栓塞的风险之间的关联.
- 确定哪些慢性疾病组合与VTE最强烈相关.
主要方法:
- 这是一项大规模的横截面研究,利用瑞典国家登记册从1997年至2015年,包括超过260万个人.
- 主要成分分析 (PCA) 用于从45种已定义的非传染性疾病中识别出9种不同的多发病性疾病集群.
- 计算了几率比率 (OR),以量化已识别的多病症集群与VTE发生之间的关联.
主要成果:
- 百分之十六的研究人口有多重疾病. 在45个非传染性疾病中,有44个与VTE相关.
- 在9个已识别的多病性群中,有7个 (F1-F9) 与VTE有显著的关联.
- 具体的集群显示有相当大的VTE风险:心脏代谢疾病 (F1) 与OR 3.44,精神障碍 (F2) 与OR 2.25,和消化系统疾病 (F3) 与OR 4.35. 集群内较高的疾病数量进一步增加了VTE风险,例如,F1中的五种疾病有OR 8.17.
结论:
- 这项全国性的研究揭示了特定多病症疾病集群和静脉血栓塞栓症之间的强烈关联.
- 已识别的疾病集群及其严重程度可以作为预测VTE风险的有价值指标.
- 了解这些复杂的疾病相互关系对于有针对性的VTE预防策略至关重要.
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