脑内麻患者的脑内巴克洛芬在控制运动功能和性严重程度方面的疗效:系统性审查和元分析
Mahdi Masrour1,2, Amir Zare1, Ana Presedo3
1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
BMC neurology
|April 27, 2024
概括
内巴克洛芬 (ITB) 疗法显著减少了大脑麻患者的性超过40%. 虽然ITB治疗也显示了运动功能的小但显著改善,但应该考虑潜在的并发症.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 儿科医学 儿科医学
背景情况:
- 性严重影响生活质量和医疗保健成本.
- 巴克洛芬是治疗的主要治疗方法.
- 大脑 (CP) 通常涉及严重的性,需要有效的干预.
研究的目的:
- 为了评估内巴克洛芬 (ITB) 治疗在治疗脑患者严重的疗效.
- 评估ITB治疗对脑患者运动功能的影响.
主要方法:
- 对PubMed,Scopus,Ovid和Cochrane图书馆进行系统审查,遵守PRISMA指南.
- 纳入标准:脑患者有性,ITB干预,通过阿什沃思尺度和总运动功能的测量 (GMFM) 测量结果.
- 使用标准化平均差异 (SMD) 随机效应模型进行统计分析.
主要成果:
- 在343名患者中观察到性减少了40.25% (SMD = -1.70,p < 0.0001).
- 在117名患者中,运动功能改善了9.62% (SMD = 0.15,p = 0.0030).
- 报告的并发症包括感染 (16.26%),脑脊液泄漏 (7.88%) 和导管/问题.
结论:
- ITB疗法在降低脑患者的性方面非常有效.
- 通过ITB治疗,可以实现对运动功能的统计学上显著的,尽管是适度的改善.
- 在治疗性时,ITB治疗的好处必须与并发症的潜在风险进行权衡.
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