[肥胖与2型糖尿病患者全因死亡风险之间的关联]
1Department of Chronic and Non-communicable Disease Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
概括
2型糖尿病患者的低体重显著增加了全因死亡风险. 相反,2型糖尿病患者的肥胖与全因死亡风险较低有关,这表明肥胖悖论.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 2型糖尿病 (T2DM) 是一个全球性的健康问题.
- 在T2DM患者中,肥胖和死亡率之间的关系仍然复杂,需要进一步调查.
研究的目的:
- 检查各种肥胖状况与2型糖尿病患者队列中全因死亡风险之间的关联.
主要方法:
- 从2016年到2021年,在江省的一个基于农村社区的T2DM队列中,有10,310名参与者被跟踪.
- 参与者根据BMI和腰围被分为六组.
- 考克斯的比例危险回归模型被用来分析所有原因的死亡风险.
主要成果:
- 与正常体重患者相比,低体重T2DM患者面临所有原因死亡风险增加104%.
- 简单的身体肥胖,复杂的超重和复杂的肥胖与全因死亡风险的降低有关 (34%,22%和38%分别).
- 亚组分析显示,不同性别和年龄的低体重患者的死亡率增加,而肥胖的老年患者 (≥65) 的死亡风险降低.
结论:
- "肥胖悖论"存在于T2DM患者的全因死亡率.
- 低体重是T2DM死亡的一个重要风险因素.
- 在T2DM患者中,某些肥胖分类与较低的全因死亡风险有关.
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