经典的HLA基因与无症状的SARS-CoV-2感染之间缺乏关联
Astrid Marchal1, Elizabeth T Cirulli2, Iva Neveux3
1Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France; University Paris Cité, Imagine Institute, Paris, France.
HGG advances
|April 28, 2024
概括
这项研究发现HLA等位基因,包括HLA-B*15:01,和无症状的SARS-CoV-2感染之间没有联系. 这些人类白细胞抗原变异并不能预测缺乏COVID-19症状.
科学领域:
- 免疫学 免疫学 免疫学
- 遗传学 遗传学是一种遗传学.
- 传染性疾病 传染性疾病
背景情况:
- I型干扰素驱动的先天免疫对于严重的COVID-19肺炎至关重要.
- 以前的研究表明,HLA-B*15:01等位基因与无症状的SARS-CoV-2感染有关,这暗示了适应性免疫的作用.
- 特定的人类白细胞抗原 (HLA) 基因对确定COVID-19感染过程的作用仍在调查中.
研究的目的:
- 在未接种疫苗的个人中调查经典HLA等位基因,特别是HLA-B*15:01和无症状的SARS-CoV-2感染之间的关联.
- 为了确定先前存在的依赖T细胞的适应性免疫力,如HLA等位基因所示,是否会影响COVID-19症状的发展.
- 为了澄清影响SARS-CoV-2感染结果的遗传因素.
主要方法:
- 来自美国前性基于人口的研究中未接种疫苗的参与者的分析 (191个无症状病例与945个有症状病例).
- 对国际COVID人类遗传力队列的检查 (206个无症状vs. 574个轻度/中度和1,625个严重/危急病例).
- 包括来自人类挑战表征研究的数据,涉及携带HLA-B*15:01等位基因的SARS-CoV-2感染个体.
主要成果:
- 在未接种疫苗的美国参与者中,在经典的HLA等位基因 (包括HLA-B*15:01) 和无症状的SARS-CoV-2感染之间没有发现相关性.
- 国际队列分析还显示,与无症状或轻度COVID-19没有显著的HLA等位基因关联.
- 人类挑战研究中的所有三个HLA-B*15:01阳性个体都出现了症状的SARS-CoV-2感染.
结论:
- 经典的HLA等位基因,包括HLA-B*15:01,似乎不会对有症状的SARS-CoV-2感染产生保护,也无法预测无症状的病程.
- 这些发现挑战了先前关于HLA-B*15:01和先前存在的适应性免疫力之间存在强烈联系的建议,从而导致无症状感染.
- 在研究的队列中,没有特定的经典HLA基因被确定为有利于SARS-CoV-2感染的无症状结局.
关键词:
在 COVID-19 疫情中,哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈协会 协会 协会 协会 协会没有症状的感染.人口分层的人口分层.更多相关视频
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