高密度脂蛋白 (HDL) 作为精神病患者人口中酒精使用的指标
Nicole M Benson1, Amin Yakubu2, Boyu Ren1
1McLean Hospital, Belmont, MA 02478, United States; Department of Psychiatry, Harvard Medical School, Boston, MA 02115, United States.
Alcohol and alcoholism (Oxford, Oxfordshire)
|April 28, 2024
概括
高密度脂蛋白 (HDL) 水平与精神健康和物质使用障碍患者的酒精使用严重程度 (AUDIT-C分数) 相相关. 然而,HDL并不是临床实践中酒精使用的一致纵向指标.
科学领域:
- 精神病学是一个精神病学.
- 临床化学 临床化学
- 公共卫生 公共卫生
背景情况:
- 酒精使用障碍识别测试-简要 (AUDIT-C) 是一种用于酒精使用的查工具.
- 高密度脂蛋白 (HDL) 是一种与心血管健康相关的脂质.
- 在精神病患者群体中,了解酒精使用与高血糖水平之间的关系对于患者护理至关重要.
研究的目的:
- 调查AUDIT-C分数与HDL水平之间的截面和纵向关联.
- 确定HDL是否可以作为精神健康/物质使用障碍 (MH/SUD) 患者酒精使用的纵向临床指标.
主要方法:
- 使用电子健康记录数据进行回顾性观察性研究.
- 包括因MH/SUD而住院的患者,近距离AUDIT-C和HDL测量.
- 线性回归模型分析了AUDIT-C和HDL之间的关联,并对共变量进行调整.
主要成果:
- 较高的AUDIT-C分数与横截面上更高的HDL水平有关.
- 随着酒精使用严重程度的增加,HDL水平在纵向上升 (中度/严重AUDIT-C).
- 观察到的HDL增加处于典型人口变化范围之内,独立于酒精使用.
结论:
- 在MH/SUD患者中,HDL水平与AUDIT-C得分相关.
- 与增加的酒精使用相关的HDL的长度增加不一致.
- HDL作为常规的MH/SUD护理中酒精使用的可靠纵向临床指标是有限的.
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