相关实验视频
Updated: Jun 27, 2025

05:42
The Forced Swim Test as a Model of Depressive-like Behavior
Published on: March 2, 2015
37.3K
揭示与埃斯基塔洛普拉姆酸盐相关的潜在不良事件:基于现实世界的分析的FDA不良事件报告系统数据库
Ying Jiang1, Yusi Cheng2, Zhiqiang Du1
1Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Jiangsu, China.
Journal of psychopharmacology (Oxford, England)
|April 28, 2024
概括
这项研究分析了FDA对埃斯基塔洛普拉姆酸盐的不良事件报告,确定了潜在的风险,如故意过量服用和未在药物标签上列出的自杀企图.
科学领域:
- 药物监督 药物监督 药物监督
- 药物安全 药物安全
- 临床研究 临床研究
背景情况:
- 埃斯基塔洛普拉姆酸盐广泛用于抑郁症和精神健康障碍.
- 了解其不良事件概况对于患者安全至关重要.
研究的目的:
- 进行与埃斯基塔洛普拉姆酸盐相关的潜在不良事件 (AE) 的多维评估.
- 使用FDA不良事件报告系统 (FAERS) 数据库识别新出现的安全信号.
主要方法:
- 使用了统计方法,包括报告几率比率 (ROR),比例报告比率 (PRR),贝叶斯信任传播神经网络 (BCPNN) 和多项目马-小鱼缩小器 (MGPS).
- 分析了FAERS从2004年第一季度到2023年第二季度的数据,包括19854个AE报告和625个首选术语 (PT).
主要成果:
- 确定了19854份关于埃斯基塔洛普拉姆酸盐的不良事件报告,其中女性和消费者是主要报告者.
- 检测到药物标签上没有出现的新出现的安全信号,包括故意过量服用,自杀企图,血清中血红素水平变化和抗动因抗体阳性.
- 大多数报告来自美国,报告在2018-2019年达到峰值.
结论:
- 虽然对心理健康状况有好处,但使用埃斯基塔洛普拉姆酸盐存在风险.
- 新出现的信号,特别是关于自杀和血清血清激素水平的变化,需要进一步调查和潜在的标签更新.
相关概念视频
Pharmacovigilance
829
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
829
Antiepileptic Drugs: Potassium Channel Activators
176
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
176
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
377
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
377
Sedatives and Hypnotics Drugs: Miscellaneous Agents
171
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
171
Antidepressant Drugs: MAOIs and Other Agents
227
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
227
Electroconvulsive Therapy
37
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
37

