循环Pepedia:自然和合成循环的知识库
Lei Liu1, Liu Yang2, Suqi Cao2
1Department of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200072, P. R. China.
Briefings in bioinformatics
|April 28, 2024
概括
循环因其抗菌性质和低毒性而显示出药物开发的前景. 一个新的数据库,CyclicPepedia,现在整合了8744个循环来帮助研究.
科学领域:
- 生物化学 生物化学
- 药用化学 医学化学
- 生物信息学是一种生物信息学.
背景情况:
- 循环对药物开发具有有利的特性,包括强大的生物活性,特异性和低毒性.
- 对于天然和合成循环的综合数据库存在重大差距.
- 现有的资源缺乏关于循环源,结构和应用的综合信息.
研究的目的:
- 介绍CyclicPepedia,一个新的,全面的循环的数据库.
- 为了整合8744个已知循环的各种信息.
- 促进循环类药物发现和开发.
主要方法:
- 开发一个综合知识网络,用于数据集成.
- 包括有关来源,分类,结构,药理动力学和物理化学性质的数据.
- 专利药物申请和相关出版物的整合.
主要成果:
- 在CyclicPepedia中,有8744个策划的循环.
- 数据库提供了一个用户友好的知识检索系统.
- 包括针对循环的专用计算工具.
结论:
- 循环Pepedia解决了对集中循环资源的需求.
- 该数据库支持循环药物化学和药物开发的研究.
- 通过可访问的数据和工具,促进该领域的进步.
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