在口腔膜状细胞癌的性别特异性生存和治疗延迟
Sandhya Kalavacherla1, Solene Poulhazan2, Emily Funk1,3
1Department of Otolaryngology-Head and Neck Surgery, UC San Diego Health, La Jolla, California, USA.
概括
女性口腔支状细胞癌 (OPSCC) 患者的生存率较差,特别是HPV阴性疾病患者. 这些妇女的治疗延迟更为常见,并且与更糟糕的结果有关,这表明潜在的系统性问题.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 头部和部癌症 头部和部癌症
背景情况:
- 口腔支状细胞癌 (OPSCC) 主要影响男性,使女性的结果受到研究不足.
- 了解性别特异性因素对于改善女性OPSCC患者的预后至关重要.
研究的目的:
- 确定影响口腔状细胞癌 (OPSCC) 结果的性别特定因素.
- 为了完善诊断OPSCC的女性患者的预后.
主要方法:
- 来自国家癌症数据库 (2004-2019) 的192,973例OPSCC病例的回顾性队列分析.
- 性别之间的社会人口统计学,临床和治疗特征的比较.
- 多变量回归模型分析存活率,治疗延迟以及它们对结果的影响.
主要成果:
- 女性 (19%) 呈现的疾病进展较慢,但生存率较差,特别是在人类乳头瘤病毒 (HPV) 阴性OPSCC (HR=1.11).
- 女性更有可能在治疗开始 (OR=1.04) 和辅助放射治疗 (OR=1.11) 中出现延迟.
- 超过60天的治疗延迟 (HR=1.17) 和辅助治疗延迟 (HR=1.24) 与女性的生存率较差有关.
结论:
- 女性OPSCC患者的生存率低于男性,特别是在HPV阴性病例中,尽管在早期阶段呈现.
- 治疗延迟,特别是辅助放射治疗,在女性中更为普遍,并显著恶化了生存率.
- 导致治疗延迟的系统因素可能是OPSCC妇女观察到的预后较差的原因.
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