在患有马凡综合征的患者中进行 mitra 门手术
Tirone E David1, Joy Park1, Chun-Po Steve Fan1
1Division of Cardiovascular Surgery of the Peter Munk Cardiac Centre, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada.
The Journal of thoracic and cardiovascular surgery
|April 28, 2024
概括
在马尔凡综合征 (MFS) 患者中,米特拉修复提供了比更换更好的生存率. 然而,经过修复后的复发性 mitrale regurgitation (MR) 影响了大约三分之一的患者在20年内.
科学领域:
- 心血管外科心血管外科
- 遗传学 遗传学 是一个
- 病理学 病理学 病理学
背景情况:
- 马凡综合征 (MFS) 是一种影响结缔组织的遗传疾病,经常导致心肌 (MV) 病理.
- 体性退化是MFS患者需要手术的主要MV病理.
研究的目的:
- 在患有马凡氏综合征 (MFS) 的患者中调查 mitra valve (MV) 的病理学.
- 为了评估MFS患者中额头肌吐 (MR) 的长期外科治疗结果.
主要方法:
- 在1988年至2020年期间,对60名MFS患者进行了MV手术进行MR的回顾性审查.
- 分析MV病理,外科手术 (修复与更换) 和长期结果,包括死亡率和重新手术.
主要成果:
- 所有患者都表现出myxomatous MV退化; 78.6%的疾病已晚期.
- 与更换 (57.8%) 相比,米特拉修复显示了显著更好的20年生存率 (6.7%).
- 在治疗20年后,中度或重度MR复发发生在36.5%的患者身上.
结论:
- 在MFS患者中,米特拉修复与更换相比,与更高的长期存活率有关.
- 尽管生存率更好,但复发性额头骨吐的显著率需要在MFS中进行MV修复后持续监测.
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