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Updated: May 12, 2026

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia
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集散RNA和单细胞测序数据的整合揭示了缺血性脑卒中中细胞形成模式和ceRNA网络

Jing Yuan1, Yu-Sha Liao1, Tie-Chun Zhang1

  • 1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan Province, China.

Translational stroke research
|April 28, 2024
PubMed
概括

这项研究揭示了缺血性中风 (IS) 后脑细胞中Abca1等关键的细胞酶基因. 这些发现突出了埃弗洛细胞酶作为一种潜在的治疗点,通过减少炎症来改善IS的恢复.

关键词:
生物信息学分析有效的细胞分裂.影响细胞形成相关的基因.炎症 炎症是一种炎症.缺血性中风是因为缺血性中风.

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Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
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An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...