一种简单可靠的二维剪切波弹性学和超声波系数减弱参数技术,用于慢性肝脏疾病
Christiane Stern1,2, An Ngo3, Cristiane Villela-Nogueira4
1Service d'Hépatologie, Hôpital Beaujon, 100 Boulevard du Général Leclerc, 92110, Clichy, France. christiane.stern@aphp.fr.
Digestive diseases and sciences
|April 28, 2024
概括
这项研究验证了Aixplorer MACH30 (SS) 用于诊断慢性肝病 (CLD) 中的肝纤维化和脂肪化. 在不同肝脏部分进行的三次测量的中位数可靠地诊断出先进的纤维化和显著的脂肪.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 医疗成像医学成像
- 诊断性的超声波检查
背景情况:
- 在慢性肝病 (CLD) 中,Aixplorer MACH30 (SS) 的性能和可靠性需要验证.
- 准确的非侵入性评估肝纤维化和肥胖症对于CLD管理至关重要.
研究的目的:
- 为CLD定义最佳的超声波弹性图 (SS) 程序.
- 评估SS的准确性,以诊断肝纤维化和肝硬化.
- 在CLD评估中建立SS的可靠性标准.
主要方法:
- 2D剪切波弹性图 (SWE) 和超声导向控制衰减参数 (SCAP) 在多个肝脏位置进行了三次.
- 使用纤维扫描 (FS) 的过渡性弹性图 (TE) 和CAP作为参考标准.
- 肝脏活检 (LB) 用于在一小部分患者的验证.
主要成果:
- 来自多个肝脏部位的三个SWE和SCAP值的中位数显示出高的诊断准确性 (纤维化AUROC为0.96,肥胖症为0.91).
- 皮肤到肝脏距离≥2.4厘米是唯一独立与测量异常相关的因素.
- 在LB,SWE和SCAP患者中,呈现出50% (纤维化) 和71% (胆固化) 的正预测值,以及94% (纤维化) 和88% (胆固化) 的负预测值.
结论:
- 艾克斯普罗勒MACH30 (SS) 提供了可靠的诊断的晚期纤维化和显著的脂肪化在CLD使用多个肝脏部分的中位数测量.
- 皮肤到肝脏距离≥2.4厘米应被视为不可靠的SS测量的标准.
- 肝硬化是对肝病严重程度的非侵入性评估的一个有价值的工具.
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