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Updated: Jun 27, 2025

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Thbs1以TGFβ-Smad2/3-ATF4依赖的方式调节骨肌肉质量

Davy Vanhoutte1, Tobias G Schips1, Rachel A Minerath1

  • 1Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Cell reports
|April 28, 2024
PubMed
概括

血栓蛋白-1 (Thbs1) 激活TGFβ-Smad3-ATF4信号传递,导致肌肉缩. 抑制这种途径部分恢复肌肉质量,这表明肌肉消耗疾病和与衰老相关的肉症的治疗标.

关键词:
在ATF4中使用ATF4.CP:新陈代谢过程中的新陈代谢.在TGFβ中,TGFβ是TGFβ.缩性缩 (英语:Atrophy atrophy) 是一种损伤.自自是自的过程.细胞外矩阵是细胞外矩阵.蛋白质酶体蛋白质组是什么这是骨肌肉的骨架肌肉.血栓支柱蛋白是什么 血栓支柱蛋白

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