相关实验视频

Updated: Jun 27, 2025

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

在不同阶段肝硬化患者的血清代谢分析

XiaoJuan Li¹, Xinxin Xu², Yu Li³

¹Department of Gastroenterology and Hepatology, Minhang Hospital, Fudan University, Shanghai, China. xiaojuanL@126.com.

Cellular and molecular biology (Noisy-le-Grand, France)

|April 28, 2024

概括

血清英多尔-3-酸 (IPA) 和临床因素可以非侵入性预测高风险肝硬化. 这一发现有助于早期识别和管理患有脱补偿风险的患者.

科学领域:

代谢学代谢学代谢学
肝病学肝病学是一种肝病学.
生物标志物发现发现

背景情况:

准确地确定肝硬化病的阶段对于患者的治疗至关重要.
需要使用非侵入性方法来识别易发生脱补偿的高风险肝硬化患者.

研究的目的:

确定血清代谢物生物标志物和临床特征,以预测高风险肝硬化.
开发一种用于非侵入性预测肝硬化脱补偿的模型.

主要方法:

在94名肝硬化患者的横截面研究中,使用了有针对性的定量代谢学.
查血清代谢物和临床数据以确定预测生物标志物.
开发和验证一种诊断模型,用于肝硬化不补偿.

主要成果:

在非补偿性肝硬化患者中,英多尔-3-酸 (IPA) 显著降低.
在区分非补偿性肝硬化 (AUC=0.79) 方面,IPA表现良好.
一个结合IPA,血红蛋白和白蛋白的模型实现了高预测性能 (AUC=0.97).

结论:

印度尔-3-酸 (IPA) 作为一种潜在的非侵入性生物标志物,用于高风险的肝硬化.
结合IPA,血红蛋白和白蛋白的诊断模型可以有效地识别患有脱补偿风险的患者.
这些发现可以帮助临床管理肝硬化.

更多相关视频

Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy

Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy

Published on: December 15, 2011

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS

Published on: March 14, 2013

相关概念视频

Serum Laboratory Studies, Stool Test, Breath Test

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...